The 3-HMG-CoA reductase inhibitors, referred to as statins, are one of the most potent lipid lowering drugs. They significantly reduce incidence of cardiovascular mortality and morbidity. Data from clinical trials and experimental evidence suggest that the observed benefits can be attributed in part to their cholesterol-lowering independent effects. Statins lower the level of hs-CRP, an important inflammatory marker, thereby reducing the risk of stroke and cardiovascular events. The need for routine assay of hs-CRP is advocated in identifying patients at risk, that may benefit from statin therapy.