eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2013-06-28 10 1 10.13005/bbra/1089 9873 article H. Faidah 1,2 M. Samy 2 A.A Tashkandi 3 Umm AL Qura University, Faculty of Medicine. Alnoor Specialist Hospital, Laboratory and Blood Bank Department National Guard Hospital, Emergency Department. This study aimed to to determine the prevalence of Sickle cell diseases and trait and high hemoglobin (Hb) A2 b- thalassemia in the province of Makkah among patients of Al-Noor Specialist hospital, Makkah. Retrospective studying the results of 620 requested saudi patients (256 male and 364 female) suffer from Anemia for gel electrophoresis. Covering the period between 1 January 2012 to 30 December 2012 was presented. It was found a significant increase (P<0.05) in prevalence of anemia among females compared to males (1.42/1 ratio). The prevalence for Sickle cell anemia was (38.38%) which showed highly significant increase comparing with (P>0.01) ²-Thalassmia (5.32%) and Non A2 Hemoglobin (2.90%). ²-Thalassmia also, showed significant increase P<0.05) compared with Non A2 Hemoglobin. Hemoglobinopathies occurs frequently among our patients, with majority of cases having Sickle cells anaemia, and cases with heterozygous mutation (trait disease) was the predominant. https://www.biotech-asia.org/vol10no1/prevalence-of-sickle-cell-anemia-and-thalassemia-among-anemic-patients-of-al-noor-specialist-hospital-makkah-ksa/ Sickle Cell Anemia; Anemic Patients; Thalassemia