eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2011-06-28 10 1 10.13005/bbra/1098 10173 article J.C. Mordi 1 U.E. Uzuegbu 1 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria. The antioxidant action of 70% ethanolic extract of fresh leaves of Cassia alata on Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities were examined using a model carbon tetrachloride (CCL4) induced oxidative damage in the liver. The administration of the extract (2.5ml and 5ml/kg body weight) significantly (p<0.05) decreased levels of CCL4 –induced formation of AST and ALP by the liver, suggesting the role of the extract in protection against pro-oxidant liver damage. Pretreatment with the extract prior to the intra-peritoneal administration of 0.5ml/kg body weight of CCL4 was reduced by 44% and 75% for AST at a dose of 2.5ml/kg body weight and 116% and 146% for ALP at 5ml/kg body weight. These findings are suggestive of the possible chemopreventive role of Cassia alata on liver damage. https://www.biotech-asia.org/vol10no1/hepatoprotective-effect-of-ethanolic-extract-of-fresh-leaves-of-cassia-alata-on-carbon-tetrachloride-induced-toxicity/ Cassia alata; Hepatoprotective; Ethanol; Carbon tetrachloride; AST; ALT