Manuscript accepted on : May 12, 2007
Published online on: 02-02-2016
Synthesis and biological screening of 2,5 -disubstituted 1,3,4 oxadiazole derivatives
Gautam*, A. K. Jain, Kuldeep Singh, Jagbir and V.K. Singh
Institute of Pharmacy Bundelkhand University, Jhansi - 284 128 (India)
ABSTRACT: Synthesis of a number of 1,3,4 – oxadiazole derivatives have been described. Benztriazole reacting with ethylcholoro acetate in the presence of potassium carbonate to produce ethyl 2 – (1H benzo[d][1,2,3] triazol – 1 yl] acetate ) which further react with hydrazine hydrate to produced (2H-benzo [d][123] triazole – 1 yl aceto hydrazide ] and this react with different aromatic acid in presence of phosphorus oxychloriede offerda 2,5 disubstituted 1,3,4 oxadiazole derivatives. Compounds were tested for antibacterial and antifungal activity.
KEYWORDS: 1,3,4 – oxadiazole derivatives and antimicrobial activity.
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| Copy the following to cite this article: Gautam, Jain A. K, Singh K, Jagbir, Singh V. K. Synthesis and biological screening of 2,5 -disubstituted 1,3,4 oxadiazole derivatives. Biosci Biotechnol Res Asia 2007;4(1) |
| Copy the following to cite this URL: Gautam, Jain A. K, Singh K, Jagbir, Singh V. K. Synthesis and biological screening of 2,5 -disubstituted 1,3,4 oxadiazole derivatives. Biosci Biotechnol Res Asia 2007;4(1). Available from: https://www.biotech-asia.org/?p=5801 |
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