Manuscript accepted on : 10 March 2015
Published online on: --
Recombinant Colicin producer Lactobacillus acidophilus and its Inhibitory Effect Against UPEC
Mehdi Moazzami Goudarzi
Department of Microbiology, Boroujerd Branch, Islamic Azad University, Boroujerd, Iran.
DOI : http://dx.doi.org/10.13005/bbra/1604
ABSTRACT: Lactobacillus species are a predominant member of vaginal microflora and play a crucial role in prevention of a number of urogenital diseases. To increase antimicrobial potential of vaginal lactobacilli, Colicin E2 possessing specific activity against uropathogenic Escherichia (E.) coli was over-expressed in vaginal probiotic lactobacillus(L.) acidophilus. Recombinant L. acidophilus expressing Colicin E2 showed much higher inhibitory activity against uropathogenic E. coli than wild type in vitro. Efficacy of probiotic L. acidophilus expressing colicin E2 protein required for further in vivo evaluation. The present study in consistent with similar studies demonstrated that the production of colicin by vaginal probiotics may increase the preventive effects of lactobacilli against urinary tract infections.
KEYWORDS: Escherichia coli; Lactobacillus acidophilus; urinary tract infections
Download this article as:
| Copy the following to cite this article: Goudarzi M. M. Recombinant Colicin producer Lactobacillus acidophilus and its Inhibitory Effect Against UPEC. Biosci Biotech Res Asia 2015;12(spl.edn.1) |
| Copy the following to cite this URL: Goudarzi M. M. Recombinant Colicin producer Lactobacillus acidophilus and its Inhibitory Effect Against UPEC. Biosci Biotech Res Asia 2015;12(spl.edn.1). Available from:http://www.biotech- asia.org/?p=12559 |
This work is licensed under a Creative Commons Attribution 4.0 International License.
